Disparate LDL Phenotypic Classification among 4 Different Methods Assessing LDL Particle Characteristics

Disparate LDL phenotypic classification among 4 different methods assessing LDL particle characteristics.

BACKGROUND Our study seeks to clarify the extent of differences in analytical results, from a clinical perspective, among 4 leading technologies currently used in clinical reference laboratories for the analysis of LDL subfractions: gradient gel electrophoresis (GGE), ultracentrifugation-vertical auto profile (VAP), nuclear magnetic resonance (NMR), and tube gel electrophoresis (TGE). METHODS...

Ldl Particle Size: Does It Matter?

LDL particle size by gradient-gel electrophoresis cannot be estimated by LDL-cholesterol/apolipoprotein B ratios.

63. 7. Gunja-Smith Z, Boucek RJ. Collagen cross-linking compounds in human urine. Biochem J 1981;197:759–62. 8. Rosen HN, Dresner-Pollak R, Moses AC, Rosenblatt M, Zeind AJ, Clemens JD, Greenspan SL. Specificity of urinary excretion of cross-linked N-telopeptides of type I collagen as a marker of bone turnover. Calcif Tissue Int 1994;54:26–9. 9. Hanson DA, Weis MA, Bollen AM, Maslan SL, Singer ...

Beyond LDL cholesterol in assessing cardiovascular risk: apo B or LDL-P?

Plasma concentrations of LDL cholesterol (LDL-C) are positively associated with increased risk of atherosclerotic cardiovascular disease. There is a variety of robust evidence indicating that this association is causal in nature. First, rare and common genetic variants that specifically influence LDL-C concentrations are also strongly associated with cardiovascular risk (1 ). Second, interventi...

Ldl Oxidation and Ldl Particle Size in the Development of Atherosclerosis

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